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Background: Insomnia is a typical complaint during pregnancy. Hormonal alterations, physiological changes during early pregnancy, and the enlargement of the foetus during late pregnancy contribute to disrupted sleep. Nursing interventions to identify sleep deficits and promote sleep are required at all stages of the maternity cycle. Methods: Insomnia, related problems and coping strategies were assessed using a structured Questionnaire of purposive sample of 50 Primigravida and 50 Multigravida Mothers attending OBG unit at HSK hospital and research centre, Bagalkot, Karnataka. Data were analyzed using descriptive and inferential statistics. Results: The result depicts that the majority of primigravida mothers (92%) experienced moderate and 8% experienced severe insomnia, 94% moderate, 4% mild and 2% experienced severe insomnia-related problems, 84% followed average, 12% good and 4% followed poor coping strategies, whereas, majority of Multigravida mothers (90%) experienced mild and 10% experienced moderate insomnia, 82% moderate and 18% experienced mild degree insomnia related problems, 92% followed average, 6% good and 2% followed poor coping strategies. There is a significant difference between primigravida mothers' insomnia, related problems and coping strategies and that of multigravida mothers. There was an irrelevant association found between insomnia scores of Primigravida and Multigravida mothers with socio-demographic variables. Conclusion: The overall study findings depicted that the mean percentage scores of insomnia of primigravida mothers (49.33%) was comparatively higher than the mean percentage scores of multigravida mothers (16.33%). Hence it was concluded that primigravida mothers has experienced more insomnia than compared to multigravida mothers.
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Background: Osteosarcoma is a malignant cancer that effect bone and metastasizing to many vital organs such as lungs. There are many available drugs to treat the disease including tamoxifen, methotrexate (MTX), and cisplatin which have their own side effects and hurdles to become drugs of choice for the disease. On the other hand, introduction of herbal drugs as chemotherapeutic agents opened up new arena to potentiate the existing treatment by exhibiting synergy. Piperine (PPN) is widely used drug as anti-cancer agent as well as it has anti-inflammatory, analgesic properties, and also used in the treatment of abdominal pains, tuberculosis, arthritis, and respiratory illness. Aims and Objective: Thus, this study was designed to investigate the synergistic inhibitory potential of PPN and MTX on the MG63 osteosarcoma cell lines in vitro. Materials and Methods: The cell lines were cultured on DMEM medium and investigated for cytotoxicity of the drugs using MTT assay at 540 nm in UV. Three groups of cell lines administered with PPN, MTX, and PPN+MTX (1:1) in various concentrations and IC50 values were calculated based on the % cell viability graphs. Results: Results showed that the IC50 of PPN was 38.65, MTX was 123.98, and PPN+MTX was 15.13 proving the significant synergistic cytotoxic effect of PPN and MTX in inhibiting the proliferation of MG63 cell lines. Conclusion: Further research needs to be conducted in this field to elucidate the synergistic pathways in which PPN has shown a better anti-osteosarcoma effect when combined with MTX.
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A cross sectional study was performed to evaluate the changes on serum lipid profile and associated risk factors in apparently healthy smoker and non-smoker students at the University of AlHikma Dhamar city, Yemen during the period between November 2021 to March, 2022. Two hundred five students were randomly selected, 104 students were smokers and 101 nonsmokers. Sociodemographic data were collected using a self-administered questionnaire. Anthropometric measurements and laboratory analysis for lipid profile were assessed using standard techniques. The results revealed that smokers had significantly (P<0.05) higher levels of TC (164.93 mg/dl), TG (149.63 mg/dl), LDL (71.60 mg/dl) and VLDL (29.58 mg/dl) and lower level of HDL (64.70 mg/dl) compared to the non-smokers group. Duration and numbers of cigarette smoked were positively correlated with lipid profile values of participants (r=.300; P=.000 and r= .317; P.=000) and (r=.210; P=.003 and r=.213; P=.002) for TG and VLDL respectively; while none with other values. Significant association was observed between weight (r=.235; P=.001 and r=.145; P=.000); heartbeat (r=.205; P=.003 and r=.256; P=.000); diastolic (r=.151; P=.030) and BMI (r=.155; P=.027) indices and lipid profile (TG and VLDL); (TC and LDL); (HDL and TC) of the participants respectively; whereas, none with height and systolic indices. In conclusion, smoking is clearly associated with increase serum lipid and lipoprotein values with exception HDL which significantly decreased in smoker compared to non-smokers students. This association is dependent on number of sociodemographic and anthropometric factors. Adopting anti-smoking programs among University`s students to prevent the harmful effects of smoking are urgently required.
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The principal objective of the present study was to check the antimicrobial activity of Actinomycetes isolated from soil samples collected from the fields of Arachis hypogea L. and Gossipium herbaceum L. against different plant pathogenic strains. Various soil samples were isolated from fields located near the Junagadh district, Gujarat, India. Isolation was followed by a serial dilution process which was later plated on Actinomycete Isolation Agar (AIA) media. Potential colonies were subjected to screening, purification, and storage in glycerol stock. Morphological and Biochemical characterization of the isolates was performed. Isolated candidates were subjected to extraction for the production of the antimicrobial compound. The antimicrobial activity of the purified extract of isolates was tested. Total 30 actinomycete isolates were evaluated for antagonistic activity against pathogenic microorganisms. Isolates C-25, C-15, and G-1 showed the best results in the decreasing order of their potency against fungal pathogens, and C-5, C-25, C-14, and C-13 showed the best results in decreasing order of potency against bacterial pathogens. 3 isolates inhibited all 4 test fungi. 10 isolates inhibited 3 test fungi. 11 isolates inhibited 2 test fungi. 6 isolates did not inhibit any test fungi. 4 isolates show potent inhibition. 15 inhibited Macrophomina. C-10 showed a 1 cm inhibition zone & G-1 showed a 0.8 cm zone of inhibition. 12 isolates gave 0.2-0.6 cm zone and 15 isolates gave negative results against Macrophomina. C-10 showed a very potent zone of inhibition of 0.7 cm. 9 isolates showed a 0.1-0.5 cm zone of inhibition. 20 isolates did not show inhibition against Fusarium. 1 isolate C-11(a) gave the 1cm potent zone of inhibition. 15 isolates gave the 0.7-0.2cm inhibition of the growth. 14 isolates gave negative results against Alternaria fungus. From these results, it was concluded that isolates had antibacterial and antifungal activities and could be used in the development of new antibiotics for pharmaceutical or agricultural purposes.
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Background: Post marketing surveillance of medical devices has to be done to avoid injuries and it is highly required to evaluate and ascertain the risks and benefits associated with the medical devices. Aims and Objectives: The aim of the study was to assess the knowledge and attitude about materiovigilance among doctors working in a tertiary care hospital. Materials and Methods: A cross-sectional study involving faculty and postgraduate residents of a tertiary care hospital using questionnaire which had 12 questions pertaining to attitude and knowledge of materiovigilance. Results: The survey questionnaire was sent to 300 health-care professionals among them, 259 respondents completely answered the questions. There were 96 teaching faculty, 163 were postgraduates residents. The average response rate was 86.3%. There was no statistical significant difference seen between the two groups (P = 0.85). Conclusion: More workshops and training programs need to be conducted to create awareness and reporting of adverse reactions due to medical instruments.
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Liver injury occurs after ischemia and reperfusion (IR), as seen in transplant settings. Sex hormones have been implicated in many pathophysiological mechanisms in females and this could lead to liver protection under inflammatory reperfusion conditions where an excessive immune response occurs. Despite such assumptions, this fact needs to be further investigated. To address this, female and male C57BL/6J mice (8-12 weeks old) were studied. Bilateral ovariectomy (OVX) was performed in females to decrease estradiol levels. IR was performed, and after two weeks, all animals underwent a sham control operation or IR with euthanasia at the following time points after reperfusion: 6, 12, 24, and 48 h. IR triggered an inflammatory process in the liver with recruitment of neutrophils into the parenchyma of male mice. The female sham mice were protected against liver IR presenting no alteration of aminotransferase (ALT) levels compared to males. OVX caused loss of protection, increasing hepatic injury as represented by increased ALT levels and myeloperoxidase (MPO) activity. Female sham mice showed increased Akt phosphorylation and activation, while males showed reduced Akt activation. Estradiol pretreatment recovered ALT levels after IR injury, which was associated with decreased liver injury.
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@#Introduction: C-reactive protein (CRP), urea, albumin, CRP/albumin ratio (CAR) and urea/albumin ratio (UAR) could be valuable biomarkers for determining the severity of illness in patients with COVID-19. This study aimed to determine the association between these markers and disease severity in COVID-19 patients on admission and days five to seven after admission. Methods: This retrospective study includes 153 adult COVID-19 patients admitted to Hospital Raja Perempuan Zainab II and Hospital Ampang from January 2021 to December 2021. Patients’ serum CRP, urea, albumin and creatinine levels were recorded on admission and on days five to seven after admission. The patients were categorised based on the Annex 2e guidelines published by the Ministry of Health, Malaysia and further classified as mild to moderate disease (stages 1-3) and severe to critical illness (stages 4-5). Results: On admission, urea, creatinine, CRP, UAR and CAR were significantly higher in the severe to critical group (p<0.001). The optimal cut-off value for the UAR was 0.16; the area under the curve (AUC) was 0.760, and sensitivity and specificity were 63.6% and 85.7%, respectively. The AUC of the CAR was 0.752, with 54.2% sensitivity and 91.4% specificity at an optimal cut-off value of 1.63. In severe to critical COVID-19 patients, albumin levels decreased significantly on days five to seven after admission, while urea levels remained significantly higher in this group (p<0.001, p<0.05, respectively). Conclusion: CRP, urea, albumin, CAR and UAR are promising biomarkers for predicting the severity of disease in COVID-19 patients.
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The study aims to explore the relationship of mental health to internal locus of control and self-efficacy of adolescents, and further to explore the differential effect of family integration on the relationship. The descriptive correlational study collected data from a random sample of 1246 adolescent learners from different secondary schools of Kerala by administering standardized psychometric instruments. Statistical analysis brought out that both internal locus of control and self-efficacy of the adolescents from broken and intact families are significantly and positively correlated to their mental health. Significant differences were observed between adolescents from broken and intact families with respect to the correlation of mental health to internal locus of control and self-efficacy. Adolescents from broken families excelled their counterparts from intact families in the degree of relationship between the variables. The study revealed that the mental health of adolescents from broken families is more strongly influenced by their internal locus of control and self-efficacy than that of adolescents from intact families
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Introduction: Forensic odontology involves the collection, management, interpretation, evaluation, and presentation of dental evidence for criminal or civil legal proceedings, a combination of various aspects of the dental, scientific and legal professions. Bite mark analysis is an essential aspect of it that can significantly impact the courtroom or when considering the care of children and women deemed at risk. Materials and Methods: Data were obtained and analyzed from previously published literature and electronic database searches of relevant published literature from PubMed and Google Scholar. Forensic odontologists examine, interpret, analyze, and prepare reports on bruises or marks thought to be caused by teeth and, on occasion, are cross-examined in a court of law. Hence, they are considered essential in forensic dentistry in solving crimes to find either suspects or even victims in self-inflicted injuries as they are caused either by humans or animals that reveal biting edges, spacing, restorations, missing teeth, broken teeth, or supernumerary teeth unique to that individual. The main reasons for causation are sexual crimes, homicides, child abuse, and violent fights. There are many methods to analyze, that are classified into manual, semi-automatic, and automatic methods. Objectives: This review highlights the bite marks in detail about their characteristics, methods of collection and different methods of analysis and its applications in forensic odontology. Conclusion: This review shows different methods of analyzing bitemarks and explains the advantages, disadvantages, and limitations, and identifies which method is better advisable and adaptableforanalysis.
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Aims: To contribute to solving plantain post-harvest losses, six preservation methods combining charcoal and polyethylene bags were experimented on three different varieties of plantain (SACI, Big-Ebanga, and Orishele). Place and Duration of Study: This work was carried out at the Biocatalysis and Bioprocesses Laboratory of Nangui Abrogoua University in Abidjan and the Food Technology Laboratory of the National Center for Agronomic Research in Côte d'Ivoire. Methodology: Some Biochemical parameters of these fruits are monitored to know the effects of these preservation methods during storage. Results: The outcomes indicate an average shelf green life extension of up to 30 days for fruits preserved in polyethylene containing charcoal, while fruits preserved in polyethylene without charcoal have only 24 days on average. The control test (fruits stored in the open air) showed an average shelf green life of 12 days. During storage, total carbohydrate levels increase and values range from 92.49% to 70.05%. Those of total sugars also increase and the levels evolve from 0.47 to 30.83 g/100 g DM. On the other hand, there is a decrease in starch levels (42.66 and 64.05 mg/100g DM). Conclusion: Charcoal can extend the shelf green life of plantain bananas for up to a month. These methods can be recommended to actors in the sector to reduce post-harvest losses.
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Introduction: Diet plays a fundamental role in the performance of athletes in general and basketball players in particular. For a better understanding of the nutrition of the athlete, this work aimed to evaluate the diet of Ivorian female basketball players in pre-competitive periods. Methodology: A retrospective frequency questionnaire survey was conducted from December 6, 2020 to the end of February 2021, on 86 female basketball players in the senior categories (17-35 years) playing in the first division. The collection of socio-demographic, anthropometric and dietary data before the competition was obtained for each team. Results: The study showed that 38.38% of the female basketball players had no side activities while 61.62% had a side activity. In general, 84.88% of the players had a normal Body Mass Index (BMI) compared to 06.98% overweight and 2.33% obese. The energy requirements of the women's teams were between 2427 and 2810 Kcal. The overall amount of energy consumed at breakfast in the pre-competitive period was below the required standards, while the amount of energy consumed at lunch and dinner was above the required standards for the players. Conclusion: In sum, the senior female basketball players of Côte d'Ivoire have a poor dietary profile. Nutritional interventions would be preferable for them in order to improve their nutritional knowledge on the one hand, and the distribution of caloric foods consumed during their different daily meals on the other hand, and to meet their energy needs.
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Context: The diagnosis of giant cell tumor of bone (GCTB) is difficult in small biopsies with unusual age of presentation, location, and extensive secondary changes. Most of the GCTBs harbor H3F3A G34W mutations with a subset of cases showing alternate G34V, G34R, and G34L mutations. Objectives: To analyze the expression of anti-histone H3.3G34W antibody in different cellular components of GCTB across different locations and presentations (including the unusual ones) and validate the utility of this antibody in the diagnosis of GCTB and differentiate it from the other osteoclast-like giant-cell-rich lesions. Design: Immunohistochemistry was performed using anti-histone H3.3G34W antibody in the diagnosed cases of GCTB (136 cases of GCTB from 133 patients, including two malignant GCTBs) and other giant cell-containing lesions (62 cases). The presence of unequivocal crisp nuclear staining was considered positive. Results: Immunohistochemistry revealed unequivocal nuclear positivity in the mononuclear cells in 87.3% of the cases of GCTB. Of these, most showed diffuse expression with moderate to strong intensity staining. The positive staining was restricted to the nuclei of mononuclear cells with the nuclei of osteoclastic giant cells being distinctly negative. In addition to conventional GCTBs, two cases each of multicentric and malignant GCTB showed positive staining. The other giant-cell containing lesions were distinctly negative. The present study showed a sensitivity of 87.3% with specificity and positive predictive value of 100%. Conclusion: The anti-histone G34W antibody is a highly sensitive and specific marker for the diagnosis of GCTB and differentiating it from its mimics. The positive staining is restricted to the mononuclear cell component of GCTB with sparing the osteoclastic giant cells further reiterating the fact that the mononuclear stromal cells are the true neoplastic component of GCTB.
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The study was carried out to determine and compare pesticide residue levels in tomatoes from Mwea Irrigation Scheme. Thirty five tomato samples of Rambo variety randomly collected from open fields, greenhouses, markets and consumers were analyzed using QuEChERS method. Results showed that pesticide residue leve;s from greenhouse tomatoes was higher compared to open fields, markets and consumers. Alpha-cypermethrin level in greenhouse tomatoes (0.0871±0.0087mg/kg) was significantly (p<0.01) higher than from consumers (0.0218±0.0061mg/kg) while difenoconazole from greenhouse tomatoes (0.2597±0.0522 mg/kg) was significantly (p<0.05) higher than from the open field (0.0295±0.0014 mg/kg). Carbendazim level in greenhouse (1.2341±0.1667 mg/kg) tomatoes was significantly (p<0.001) higher than from open fields (0.0596±0.0178 mg/kg), markets (0.1160±0.0490 mg/kg) and consumers (0.0494±0.0155 mg/kg). Imidacloprid in greenhouse tomatoes (0.1446±0.0086 mg/kg) was significantly (p<0.001) higher than from the markets (0.0236±0.0019 mg/kg) and consumers (0.0170±0.0017 mg/kg). High pesticide residue levels in tomatoes are a health concern for consumers. Enforcing the food safety laws, enhancing farmer training on safe use of pesticides and creating awareness on pesticide risks would promote production of uncontaminated crops consumed locally.
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Aims: The aqueous extract of cashew apple cakes, rich in molecules of pharmacological interest, could be used against many diseases. Thus, the aim of the present work is to evaluate its hepatoprotective activity in rats and mice. Methodology: Two batches of rats weighing between 200 and 300 grams, with five rats per batch, were pretreated for eleven days with the aqueous extract of cashew apple cakes at concentrations ranging from 150 to 300 mg.Kg-1 bw, then intoxicated with paracetamol at 2 g.Kg-1 bw, for three days. The blood of these rats was collected and submitted to biochemical analyses. Two batches of mice weighing between 20 and 30 grams, with five mice per batch, were pretreated with the same test substance at concentrations also ranging from 150 to 300 mg.Kg-1 bw, then intoxicated with paracetamol before receiving phenobarbital. Afterwards, their sleep time was evaluated. Results: In rats, paracetamol intoxication materialized by the increase in serum ALT activity ranging from 109±5.19 to 571±20.28 IU.L-1 and that of AST ranging from 144±5.77 to 428±14.19 IU.L-1. Similarly, direct bilirubin increased from 0 to 1.08± 0.58 mg.dl-1. These increases in transaminase activity and bilirubin levels were significantly decreased in rats pretreated with the aqueous extract of cashew apple cake. In mice, the phenobarbital test showed a 29.82 to 38.59% decrease in sleep time in mice pretreated with the aqueous extract of cashew apple cakes. Conclusion: The aqueous extract of cashew apple cakes influencing biochemical parameters such as ALT, AST, bilirubin and sleep time, could therefore be used in the prevention of liver diseases, in traditional medicine.
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Oral cavity cancers are part of the upper aerodigestive tract cancers and represent a significant burden worldwide. Its epidemiology varies from country to country with high frequencies in South East Asian countries. Tobacco and alcohol are the main risk factors. Survival of oral cancer is low i.e., less than 40% in the advanced stage (stage III and IV), diagnosis of oral cavity cancer is based on a complete clinical examination of the oral cavity complete with biopsy, bio-markers are an adjunct to screening and diagnosis of oral cavity cancers, surgery, radiotherapy, chemotherapy and immunotherapy are part of the therapeutic armamentarium of oral cancer but also have limitations. Traditional medicine is an important and proven alternative in the treatment and support of patients with oral cavity cancer. Prevention of oral cavity cancers includes not only early detection of precancerous and cancerous lesions but also control of risk factors and education of the population. Surgery, radiotherapy, chemotherapy and immunotherapy are part of the therapeutic strategy of oral cancer treatment but also have limitations. Traditional Medicine is an important and proven alternative in the treatment and support of patients with oral cavity cancer. It is thus desirable to scientifically validate phytochemicals in order to integrate alternative medicine as part of national cancer management strategy. In silico advanced studies on secondary metabolites of medicinal plants traditionally used to treat oral cancer are in progress.
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Aim: The objective of this study was to determine the phytochemical profile of Senna alata LINN using chemical screening in solution and thin-layer chromatography, and to assess the antioxidant and anthelmintic activities of the plant抯 aqueous extracts. Methodology: All the analyses performed in this study were, respectively, done as described by the standard protocols. These were: the microscopic examination of the plant powders performed using a light microscope, the search for secondary metabolites carried out by chemical screening in solution and by thin-layer chromatography, the determination of the secondary metabolites, and the antioxidant activity carried out by UV-visible spectroscopy and the anthelmintic activity performed by dilution in decreasing order of concentration. Results: Micrographic analysis of the powder of Senna alata revealed the histological elements rich in unicellular covering hairs with a punctate surface and in fragments of palisade parenchyma, with elongated cells. The presence of polyphenols (flavonoids, anthocyanins, tannins, leuco anthocyanins, free quinones), steroids, terpenoids, and iridoids was detected by phytochemical screening in solution and confirmed by thin-layer chromatography. The determination of total phenolic compounds, flavonoids, total tannins, and anthocyanins showed that Senna alata contains 254.64 mg EQ/g, 12.3%, 9.5%, and 6.5%, respectively, of these metabolites. The aqueous extract of the leaves of Senna alata showed a good anthelmintic activity after 41 minutes of exposure to 5.00 mg/mL of the extract and the antioxidant activity was reported, of which the value of IC50 ( g/mL) of the extract for the DPPH tests is 91.42 15.56. Conclusion: Histological elements rich in unicellular covering hairs with a punctate surface and in fragments of palisade parenchyma, with elongated cells were revealed in the micrographic analysis of Senna alata. The plant抯 leaf methanol extract showed good antioxidant activity, while the anthelmintic activity was demonstrated in its aqueous extract.
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Aims of the Study: To identify plant species traditionally used to treat anemia in Yakoma territory and to evaluate their chemical composition. Place and Duration: Yakoma Territory (survey) and University of Kinshasa (Phytochemical study), from August and October 2019. Methods: Ethnobotanical survey according to the "snowball" sampling technique among traditional healers (based on the free consent of the respondents), chemical analyses of plant materials (chemical screening, TLC, phytomarkers content, minerals composition) according to standard methods. ED-XRF was used for mineral analysis. Microsoft Excel version 2010, Origin version 8.5 Pro and IBM SPSS statistics version 20 software packages were used for data processing and analysis. Results and Discussion: The survey showed that 18 plant species are traditionally used by Ngbandi traditional healers to treat anemia in Yakoma territory. They belong to 16 families and 17 genera. The most used organs are the leaves (68.4%) and the roots (10.5%). Decoction and infusion are the most used mode of preparation (33.3% each), followed by cooking (22.2%) and maceration (11.1%). The oral route (77.8%) is the most used mode of administration followed by the enema (16.7%) and the anal route (5.6%). Morphological types consist of herbs and trees (33.3% each) and shrubs and lianas (16.7% each). The biotope types consist of forest plants (44.4%), cultivated plants/Crops (38.9%), marshy ground plants (11.1%) and ruderal plants (5.6%). These plants belonging to five biological types: erected therophytes (44.4%), mesophanerophytes (27.8%), microphanerophytes and climbing phanerophytes (11.1% each) and lianescent phanerophytes (5.56%). These anti-anemic plant species are mostly Pantropical and Afro-tropical (39% of species each) followed by Guineo-Congolese (17% of species) and American (5%). Chemical analysis revealed the presence of alkaloids, anthocyanins, flavonoids, anthraquinones and terpenoids and various minerals including iron, zinc, copper, calcium, magnesium and manganese. Conclusion: In the current state of knowledge, the survey of anemic plants from this part of the Democratic Republic of the Congo is reported for the first time.
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Background & objectives: In this study, we aimed to investigate the relationship between serum TGF-?1 and PDGFB levels with the pathogenesis, clinical course and prognosis of adult Crimean-Congo hemorrhagic fever (CCHF) patients. Methods: 50 adult patients and 30 healthy individuals as a control group were included in the study, who were followed up and treated with the diagnosis of CCHF at the Atatürk University Faculty of Medicine Infectious Diseases and Clinical Microbiology Clinic, between March 2017 and September 2019 in Eastern Anatolia Region in Turkey. Blood samples were taken from patients on the first day of their hospitalization and on the sixth day of their complaints. TGF-?1 and serum PDGF-B levels were studied by ELISA method using commercial kits, from serum samples taken from CCHF patient group and individuals in healthy control group and stored at -80°C. Results: While the serum TGF- ?1 levels of patients with CCHF were found to be significantly higher on the sixth day of their complaints compared to the first day of hospitalization (42.33 ± 15.42, 28.40 ± 7.06, p = 0.001, respectively), the serum PGDF-B levels were found to be significantly lower on the sixth day of their complaints compared to those measured on the day of hospitalization (62.14 ± 19.75, 93.96 ± 20.02, respectively, p = 0.001). Interpretation & conclusion: Serum TGF-?1 levels are higher and PDGF-B levels are lower in CCHF patients with severe disease, indicating that serum TGF-?1 and PDGF-B play an important role in the pathogenesis of CCHF
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Background/Aims: In this study, we investigated the Golgi protein 73 (GP73) level in Hepatitis B and determined the correlation between Hepatitis B virus (HBV) DNA, alanine aminotransferase (ALT), aspartate aminotransferase (AST) levels, and liver histopathology. Materials and Methods: GP73 levels were estimated by enzyme-linked immunosorbent assay in serum samples from patients. Liver biopsy specimens were examined by the same pathologist. Results: This study included a total of 127 patients who underwent liver biopsy. Of patients, 85% were HBeAg negative. HBV DNA level was median 134667 IU/mL (2247–170000000 IU/mL), Liver biopsy results revealed a mean Histological Activity Index (HAI) grade of 7.7 ± 3.4 and a mean fibrosis stage of 2.25 ± 1.06 gr/dL. GP73 was as follows: a mean of 14.8 ± 7.9 ng/mL and a median of 12.9 (4.8–50.1) ng/mL. A weak correlation between GP73 level and AST (r = 0.236, P = 0.11), fibrosis stage (r = 0.287, P = 0.002), and HAI grade (r = 0.218, P = 0.016) was noted. No statistically significant correlation was detected between GP73 and ALT (r = 0.16, P = 0.08), HBV DNA (r = 0.13, P = 0.08). Conclusion: Although recent studies revealed a strong correlation and increased GP73 levels in accordance with HAI scores and the fibrosis grade of liver, we detected a weak correlation between serum GP73 levels and HAI scores, fibrosis stage, and AST. This may be due to the insufficient number of patients with higher HAI grading and fibrosis staging in our study. Therefore, we concluded that, in cases of low-moderate fibrosis and HAI grading, GP73 seemed not to be useful and a reliable marker to replace liver biopsy.